Eleuthero (Eleutherococcus senticosus), also known as Siberian ginseng, has been used for centuries to prevent colds and flu, enhance immune system, and increase energy, longevity and vitality. Famed as an energy tonic since ancient times, Eleuthero only gained recognition in the West in the 1950s, when a Russian scientist (I. I. Brekhman) reported its notable stress-relieving powers. Good scientific evidence has also been documented, in which Eleuthero increased endurance and mental performance in patients with mild fatigue and weakness.

Although it shares similar properties with Chinese or American (Panax) ginseng, each belongs to a different genus. The active ingredient of Eleuthero is eleutherosides, while panax ginseng’s active ingredient is ginsenosides. The major constituents of Eleuthero are Ciwujianoside A-E, Eleutheroside B (Syringin), Eleutherosides A-M, Friedelin, and Isofraxidin. Among them, Eleutheroside B and Eleutheroside E are the two main active and marker chemical components.

With the strict control of raw materials and innovative extraction technology, our Canphy® Eleuthero P.E. is consistent in the product standard of U.S. Pharmacopeia (USP), containing no less than 0.8 percent of Eleutheroside B and E [1]. CPC can evaluate the potency of the Eleuthero P.E. within 8 minutes using RR-HPLC, and the chromatographic profile characterized with both Eleutheroside B and Eleutheroside E. Alternatively, we successfully developed a RRLC method for fast simultaneous determination of Eleutheroside B and E and other marker compounds in commercial polyherbal formulated products containing Rhodiola rosea extract and Eleuthero extract [2].


[1] The united states pharmacopeial convention. USP 30 Volumn 1. 2007. P 924.

[2] Yuan-chun Ma, Xiao-Qiang Wang, FeiFei Hou, Jie Ma, etc. Simultaneous quantification of polyherbal formulations containing Rhodiola rosea L. and Eleutherococcus senticosus Maxim. using rapid resolution liquid chromatography (RRLC). Journal of Pharmaceutical and Biomedical Analysis (2011)55,908-915.

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